Endocrine Abstracts

Introduction: There is increasing evidence for a role of the CRH/urocortin family in human pregnancy, since they have been implicated both in physiological processes and pathogenesis of diseases such as spontaneous preterm labour. However, little information is available on the presence or function of the CRH/urocortin genes in mouse pregnancy. The study aimed to investigate the expression of CRH, urocortins and their receptors in mouse utero-placental tissues during late preg...

Preterm delivery (PTD) and preeclampsia (PE) are ‘obstetric syndromes’, characterized by complex pathogenesis and representing major causes of perinatal mortality and morbidity. Although therapeutical treatment have been developed, their incidence is not reducing. Prevention aims to preclude development of disease by eliminating/reducing risk in women with known risk factors.The feto-placental unit produces hormonal/neuronal/immune factors, cru...